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Obesity and early intervention

Is obesity irreversible? Timing is everything when it comes to weight loss.

ANN ARBOR, Mich. — Joint research between the University of Michigan and the Argentina-based National Council of Science and Technology (CONICET) has shed light on one of the most frustrating mysteries of weight loss – why the weight inevitably comes back.

A novel animal model showed that the longer mice remained overweight, the more “irreversible” obesity became, according to the study.

Over time, the static, obese state of the mice reset the “normal,” body weight set point to become permanently elevated, despite dieting that initially worked to shed pounds, authors say.

One of the major strengths of the research was a new model of obesity-programmed mice that allowed weight loss success to be tracked at different stages and ages by flipping a genetic switch that controls hunger. (SOURCE: University of Michigan)

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